FIGNL1

Across TCGA pan-cancer cohorts, FIGNL1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FIGNL1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FIGNL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FIGNL1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD, KIRP, and BLCA are the cancer types where FIGNL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FIGNL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+2.036	<.001	11	view →
KIRP	All	IV	+1.682	<.001	11	view →
BLCA	Male	III,IV	+1.631	<.001	11	view →
KIRC	Male	All	+0.624	<.001	11	view →
COAD	Male	All	+1.206	<.001	10	view →
HNSC	Male	All	+0.974	<.001	10	view →
STAD	All	III,IV	+1.346	<.001	9	view →
LIHC	Male	All	+1.162	<.001	9	view →
LUSC	Female	All	+1.751	<.001	6	view →
BRCA	All	II,III,IV	+0.495	<.001	6	view →
READ	All	All	+0.802	<.001	5	view →
CHOL	Male	All	+1.838	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FIGNL1–LUAD

Open the LUAD breakdown →