FIGNL1

Across TCGA cell cohorts, FIGNL1 mutation is significantly associated with the RNA expression of many other genes, with 679 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FIGNL1-associated genes across cancer lineages are OR10H3, RGR, and CLRN1. Each is linked with FIGNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FIGNL1-to-partner and partner-to-FIGNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H3 grouped by FIGNL1-low versus FIGNL1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FIGNL1→partner) and Y-score (partner→FIGNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR10H3 →	+0.049	+5.000	<.001	.005	3	1
URINARY_TRACT	RGR →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	CLRN1 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	HTR1A →	+0.030	+5.087	<.001	.004	3	1
STOMACH	DAOA →	+0.060	+5.285	<.001	.003	3	1
OVARY	KRTAP20-2 →	+0.096	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 679 associations by consensus.

OR10H3 by FIGNL1 expression — KIDNEY

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