FHL2

Across TCGA patient cohorts, FHL2 mutation is significantly associated with the RNA expression of many other genes, with 2,638 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FHL2-associated genes across cancer lineages are RPL17P49, RNA5SP113, and MTHFD2P3. Each is linked with FHL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FHL2-to-partner and partner-to-FHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P49 grouped by FHL2-low versus FHL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FHL2→partner) and Y-score (partner→FHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL17P49 →	+0.055	+2.767	.009	.003	3	3
LUAD	RNA5SP113 →	+0.839	+4.798	<.001	.006	3	2
BLCA	MTHFD2P3 →	+0.127	+4.444	<.001	.006	3	2
BLCA	RN7SKP43 →	+0.130	+5.040	<.001	.002	3	2
UCEC	RNU6-1213P →	+0.157	+3.214	<.001	.004	3	2
BLCA	OR7G15P →	+0.117	+4.177	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,638 associations by consensus.

RPL17P49 by FHL2 expression — UCEC

Explore this box plot interactively →