FGFR4

Across TCGA cell cohorts, FGFR4 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FGFR4-associated genes across cancer lineages are MS4A10, HMGB4, and FAM71C. Each is linked with FGFR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGFR4-to-partner and partner-to-FGFR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by FGFR4-low versus FGFR4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR4→partner) and Y-score (partner→FGFR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MS4A10 →	+0.006	+4.867	<.001	.009	3	2
OESOPHAGUS	HMGB4 →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	FAM71C →	+0.023	+4.906	<.001	.006	3	1
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP17L18 →	+0.006	+4.887	<.001	.009	3	1
BLOOD_Leukemia	NPPB →	+0.138	+3.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MS4A10 by FGFR4 expression — BLOOD_Lymphoma

Explore this box plot interactively →