FGFR4

Across TCGA pan-cancer cohorts, FGFR4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FGFR4 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher FGFR4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGFR4 expression acts as an unfavorable survival marker, although some lineages such as UCS and STAD show a favorable association.

UVM, LIHC, and UCS are the cancer types where FGFR4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.430	0.875	<.001	84	view →
LIHC	DFS	Median	All	0.469	0.615	<.001	54	view →
UCS	DFS	Median	II,III,IV	0.577	0.143	<.001	54	view →
THCA	DFS	Median	II,III,IV	0.852	0.952	<.001	49	view →
MESO	DFS	Tertile	II,III,IV	0.283	0.465	.017	34	view →
BLCA	DFS	Median	All	0.173	0.490	.004	30	view →
KICH	OS	Median	All	0.695	1.000	.004	27	view →
SKCM	OS	Tertile	All	0.728	0.828	.003	27	view →
LGG	DFS	Median	All	0.659	0.804	<.001	21	view →
HNSC	OS	Median	All	0.301	0.494	.005	18	view →
THYM	DFS	Median	All	0.842	0.959	.012	16	view →
ESCA	OS	Quartile	All	0.381	1.000	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FGFR4–UVM (DFS)

Open the UVM breakdown →