FGFR3

Across TCGA cell cohorts, FGFR3 mutation is significantly associated with the RNA expression of many other genes, with 971 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGFR3-associated genes across cancer lineages are ASIP, ACBD5, and RCN2. Each is linked with FGFR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGFR3-to-partner and partner-to-FGFR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASIP grouped by FGFR3-low versus FGFR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR3→partner) and Y-score (partner→FGFR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASIP →	+0.306	+3.489	.004	.001	3	2
BLOOD_Leukemia	ACBD5 →	+0.608	+3.489	<.001	.001	3	2
BLOOD_Leukemia	RCN2 →	+0.675	+3.489	.007	.001	3	2
LARGE_INTESTINE	EXOSC9 →	+0.557	+3.169	.006	.009	3	2
LARGE_INTESTINE	CAPN7 →	+0.548	+2.502	<.001	.005	3	2
BLOOD_Leukemia	THUMPD3 →	+0.402	+3.489	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 971 associations by consensus.

ASIP by FGFR3 expression — BLOOD_Leukemia

Explore this box plot interactively →