FGFR3

Across TCGA pan-cancer cohorts, FGFR3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FGFR3 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FGFR3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGFR3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

UCEC, UVM, and CHOL are the cancer types where FGFR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	IV	0.469	0.862	.004	58	view →
UVM	DFS	Median	All	0.442	0.793	<.001	54	view →
CHOL	DFS	Median	All	0.230	0.714	.001	46	view →
ACC	DFS	Quartile	All	0.135	0.775	.004	46	view →
BRCA	OS	Tertile	III,IV	0.744	0.321	<.001	43	view →
LGG	OS	Median	All	0.748	0.859	<.001	40	view →
KIRC	OS	Quartile	All	0.942	0.825	.008	34	view →
THCA	DFS	Tertile	II,III,IV	0.609	0.949	<.001	29	view →
CESC	DFS	Median	All	0.873	0.766	.006	26	view →
LIHC	DFS	Tertile	II,III,IV	0.150	0.340	<.001	23	view →
DLBC	DFS	Median	III,IV	0.074	0.984	.003	20	view →
MESO	DFS	Median	IV	0.166	0.459	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FGFR3–UCEC (DFS)

Open the UCEC breakdown →