FGFR3

Across TCGA pan-cancer cohorts, FGFR3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FGFR3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FGFR3 RNA is repressed in tumor relative to normal tissue. In most cancer types FGFR3 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where FGFR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGFR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−5.803	<.001	9	view →
KIRC	Male	All	−0.881	<.001	9	view →
LUAD	Male	II,III,IV	−1.713	<.001	8	view →
KIRP	Male	All	−1.840	<.001	6	view →
BRCA	All	III,IV	+1.361	<.001	6	view →
COAD	All	II,III,IV	−0.673	.006	6	view →
LIHC	All	All	+0.514	.017	4	view →
CHOL	Female	All	+3.236	<.001	3	view →
THCA	All	All	+0.708	<.001	3	view →
LUSC	All	All	+0.965	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FGFR3–KICH

Open the KICH breakdown →