FGFR1

Across TCGA patient cohorts, FGFR1 mutation is significantly associated with the RNA expression of many other genes, with 2,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGFR1-associated genes across cancer lineages are CHAF1A, ERP27, and SENP3-EIF4A1. Each is linked with FGFR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FGFR1-to-partner and partner-to-FGFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by FGFR1-low versus FGFR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGFR1→partner) and Y-score (partner→FGFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.474	+1.436	.001	.006	3	4
UCEC	ERP27 →	-1.058	-1.858	<.001	.002	3	4
UCEC	SENP3-EIF4A1 →	+0.074	+3.099	.006	<.001	3	3
UCEC	CDT1 →	+0.665	+1.676	<.001	.001	3	3
UCEC	LPL →	-0.547	-2.485	.001	<.001	3	3
UCEC	TYMSOS →	+0.631	+1.676	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,029 associations by consensus.

CHAF1A by FGFR1 expression — UCEC

Explore this box plot interactively →