FGF21

Across TCGA patient cohorts, FGF21 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,666 significant associations in total. STAD shows the largest number of these associations.

The most reproducible FGF21-associated GO terms across cancer lineages are Positive regulation of triglyceride catabolic process, Outer mitochondrial membrane organization, and Mitochondrial translation. Each is linked with FGF21 in more than 15 cancer types. Because this analysis shows association rather than direction, both FGF21-to-partner and partner-to-FGF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of triglyceride catabolic process grouped by FGF21-low versus FGF21-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF21→partner) and Y-score (partner→FGF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Positive regulation of triglyceride catabolic process →	-0.197	-1.179	<.001	<.001	3	16
ESCA	Outer mitochondrial membrane organization →	+0.060	+0.244	<.001	<.001	3	13
STAD	Mitochondrial translation →	+0.064	+0.089	<.001	<.001	3	12
CHOL	L-serine biosynthetic process →	+0.120	+1.952	<.001	.005	3	12
STAD	Positive regulation of cell cycle G2/M phase transition →	+0.059	+0.094	<.001	<.001	3	12
STAD	Regulation of RNA binding →	+0.039	+0.103	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,666 associations by consensus.

Positive regulation of triglyceride catabolic process by FGF21 expression — SCLC

Explore this box plot interactively →