FGF21

Across TCGA pan-cancer cohorts, FGF21 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated FGF21 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FGF21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGF21 expression acts as an unfavorable survival marker, although some lineages such as LIHC and READ show a favorable association.

KIRC, ACC, and KICH are the cancer types where FGF21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.537	0.668	<.001	128	view →
ACC	DFS	Median	All	0.387	0.720	<.001	97	view →
KICH	OS	Quartile	All	0.667	1.000	<.001	84	view →
UCEC	DFS	Quartile	All	0.858	0.918	.006	60	view →
MESO	DFS	Tertile	II,III,IV	0.096	0.547	<.001	54	view →
BRCA	OS	Quartile	IV	0.433	0.817	<.001	53	view →
CHOL	OS	Median	II,III,IV	0.213	0.895	<.001	45	view →
THYM	DFS	Quartile	II,III,IV	0.403	0.875	.007	43	view →
LGG	DFS	Tertile	All	0.564	0.781	<.001	30	view →
BLCA	DFS	Tertile	III,IV	0.256	0.530	<.001	27	view →
PCPG	OS	Quartile	All	0.803	1.000	.002	27	view →
LAML	DFS	Quartile	All	0.267	0.512	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

FGF21–KIRC (DFS)

Open the KIRC breakdown →