FGF21

Across TCGA pan-cancer cohorts, FGF21 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FGF21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FGF21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FGF21 is over-expressed in tumor, although a few such as CHOL show the opposite, repressed pattern.

KIRC, UCEC, and KIRP are the cancer types where FGF21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.038	.034	5	view →
UCEC	All	All	+0.286	.002	4	view →
KIRP	All	All	+0.058	.024	4	view →
CHOL	All	All	−3.247	<.001	3	view →
KICH	All	All	+0.253	.015	3	view →
LUSC	Male	All	+0.154	<.001	2	view →
COAD	All	All	+0.043	.015	2	view →
LUAD	Female	All	+0.018	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FGF21–KIRC

Open the KIRC breakdown →