FGF21

Across TCGA patient cohorts, FGF21 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF21-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and A-Raf_pS299. Each is linked with FGF21 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF21-to-partner and partner-to-FGF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FGF21-low versus FGF21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF21→partner) and Y-score (partner→FGF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.908	+3.019	.008	.019	3	1
UCEC	EGFR_pY1068 →	-0.305	-3.000	.035	.037	1	1
UCEC	A-Raf_pS299 →	-0.144	-3.000	.037	.037	1	1
UCEC	p27_pT198 →	+0.123	+3.000	.046	.037	1	1
UCEC	Caspase-8 →	-0.286	-3.000	.049	.037	1	1
UCEC	c-Jun_pS73 →	-0.223	-3.000	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by FGF21 expression — UCEC

Explore this box plot interactively →