FGF21

Across TCGA cell cohorts, FGF21 RNA expression is significantly associated with the go_rna of many other GO terms, with 825 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FGF21-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, L-amino acid biosynthetic process, and Proteinogenic amino acid biosynthetic process. Each is linked with FGF21 in more than 8 cancer types. Because this analysis shows association rather than direction, both FGF21-to-partner and partner-to-FGF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress grouped by FGF21-low versus FGF21-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF21→partner) and Y-score (partner→FGF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.128	+0.781	<.001	.004	3	9
SOFT_TISSUE	L-amino acid biosynthetic process →	+0.082	+0.870	<.001	.009	3	8
BLOOD_Leukemia	Proteinogenic amino acid biosynthetic process →	+0.069	+0.088	<.001	.007	3	6
BLOOD_Leukemia	Regulation of response to endoplasmic reticulum stress →	+0.027	+0.085	.009	.009	3	6
OESOPHAGUS	Serine family amino acid biosynthetic process →	+0.218	+0.412	<.001	.006	2	7
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	+0.089	+0.864	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 825 associations by consensus.

Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress by FGF21 expression — BREAST

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