FGF21

Across TCGA cell cohorts, FGF21 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FGF21-associated genes across cancer lineages are SLC10A2, OR10J1, and CCDC195. Each is linked with FGF21 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF21-to-partner and partner-to-FGF21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC10A2 grouped by FGF21-low versus FGF21-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF21→partner) and Y-score (partner→FGF21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1
SKIN	OR10J1 →	+0.021	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	CCDC195 →	+0.044	+4.467	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SLC10A2 by FGF21 expression — SKIN

Explore this box plot interactively →