FGF1

Across TCGA patient cohorts, FGF1 mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF1-associated genes across cancer lineages are POM121C, OR6R2P, and MIR6766. Each is linked with FGF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF1-to-partner and partner-to-FGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121C grouped by FGF1-low versus FGF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF1→partner) and Y-score (partner→FGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POM121C →	+0.476	+3.346	.002	.005	3	1
UCEC	OR6R2P →	+0.312	+2.061	<.001	.008	3	1
UCEC	MIR6766 →	+0.350	+3.037	<.001	.002	3	1
UCEC	RN7SL478P →	+0.336	+2.354	<.001	.003	3	1
COAD	OR1L1 →	+0.095	+5.003	.005	.004	3	1
UCEC	WHAMM →	+0.707	+3.201	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

POM121C by FGF1 expression — UCEC

Explore this box plot interactively →