FGF1

Across TCGA pan-cancer cohorts, FGF1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FGF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FGF1 RNA is repressed in tumor relative to normal tissue. In most cancer types FGF1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where FGF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−4.421	<.001	12	view →
KIRP	Female	II,III,IV	−4.988	<.001	11	view →
KICH	All	III,IV	−3.807	<.001	10	view →
THCA	All	III,IV	+1.196	<.001	9	view →
BRCA	Female	All	−1.984	<.001	6	view →
CHOL	All	All	+1.726	.003	3	view →
STAD	Female	All	−0.878	.013	2	view →
PRAD	All	All	−0.371	.004	2	view →
READ	Female	All	−1.182	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FGF1–KIRC

Open the KIRC breakdown →