FES

Across TCGA patient cohorts, FES mutation is significantly associated with the RNA expression of many other genes, with 3,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FES-associated genes across cancer lineages are CHAC2, RBBP4, and HIRA. Each is linked with FES in more than 2 cancer types. Because this analysis shows association rather than direction, both FES-to-partner and partner-to-FES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAC2 grouped by FES-low versus FES-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FES→partner) and Y-score (partner→FES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CHAC2 →	+0.673	+3.591	.005	.001	3	3
SKCM	RBBP4 →	+0.594	+3.341	.004	.005	3	3
UCEC	HIRA →	+0.361	+2.839	.008	.001	3	3
UCEC	NCAPG →	+0.586	+2.708	.008	.003	3	3
UCEC	MRPL37 →	+0.491	+2.807	<.001	<.001	3	3
UCEC	SDHB →	+0.462	+2.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,136 associations by consensus.

CHAC2 by FES expression — SKCM

Explore this box plot interactively →