FES

Across TCGA pan-cancer cohorts, FES RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FES’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FES RNA is repressed in tumor relative to normal tissue. In most cancer types FES is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, KIRC, and LUSC are the cancer types where FES tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FES RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.563	<.001	10	view →
KIRC	Female	All	+0.778	<.001	10	view →
LUSC	Male	II,III,IV	−1.493	<.001	8	view →
LUAD	Female	All	−0.538	<.001	7	view →
UCEC	All	III,IV	−1.703	<.001	6	view →
BRCA	All	II,III,IV	−0.932	<.001	6	view →
BLCA	Male	III,IV	−0.829	.006	6	view →
KIRP	All	II,III,IV	−0.754	.012	6	view →
STAD	Male	II,III,IV	+0.825	.017	5	view →
PAAD	Male	All	−0.859	.048	2	view →
PRAD	All	All	−0.792	<.001	2	view →
THCA	All	All	−0.207	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FES–KICH

Open the KICH breakdown →