FES

Across TCGA pan-cancer cohorts, FES RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FES data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher FES RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FES expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LGG, LUSC, and HNSC are the cancer types where FES RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.352	0.534	<.001	52	view →
LUSC	DFS	Median	III,IV	0.165	0.843	<.001	51	view →
HNSC	DFS	Tertile	III,IV	0.420	0.262	<.001	50	view →
UCEC	OS	Median	III,IV	0.900	0.764	.006	46	view →
UVM	DFS	Tertile	All	0.605	0.893	.001	36	view →
PAAD	OS	Median	II,III,IV	0.667	0.440	.002	25	view →
SKCM	OS	Median	II,III,IV	0.796	0.883	.001	25	view →
SARC	OS	Quartile	All	0.830	0.612	<.001	19	view →
GBM	OS	Quartile	All	0.295	0.458	.008	18	view →
STAD	OS	Quartile	All	0.304	0.611	.001	18	view →
ACC	OS	Median	III,IV	0.186	0.751	.004	17	view →
MESO	DFS	Median	III,IV	0.467	0.288	.015	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FES–LGG (OS)

Open the LGG breakdown →