FES

Across TCGA patient cohorts, FES mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FES-associated genes across cancer lineages are p90 RSK, MSH2, and PCNA. Each is linked with FES in more than 1 cancer types. Because this analysis shows association rather than direction, both FES-to-partner and partner-to-FES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by FES-low versus FES-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FES→partner) and Y-score (partner→FES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	p90 RSK →	+0.330	+3.000	.003	.033	3	2
UCEC	MSH2 →	-0.246	-2.105	.006	.017	3	2
UCEC	PCNA →	+0.231	+1.906	.006	.015	3	2
UCEC	ATM →	-0.497	-2.000	.005	.010	3	2
UCEC	c-Myc →	-0.219	-2.459	.023	.019	3	2
UCEC	C-Raf →	+0.146	+2.115	.009	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

p90 RSK by FES expression — STAD

Explore this box plot interactively →