FES

Across TCGA cell cohorts, FES mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FES-associated genes across cancer lineages are TAS2R39, FBXW10, and SPACA3. Each is linked with FES in more than 1 cancer types. Because this analysis shows association rather than direction, both FES-to-partner and partner-to-FES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by FES-low versus FES-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FES→partner) and Y-score (partner→FES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAS2R39 →	+0.041	+3.339	.003	.006	3	2
LARGE_INTESTINE	FBXW10 →	+0.215	+3.714	<.001	<.001	3	2
SOFT_TISSUE	SPACA3 →	+0.169	+3.999	<.001	.004	3	1
SOFT_TISSUE	IL22RA2 →	+0.039	+3.882	<.001	.004	3	1
SOFT_TISSUE	OR4F4 →	+0.011	+4.169	<.001	.002	3	1
SOFT_TISSUE	OR52N4 →	+0.062	+3.882	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

TAS2R39 by FES expression — BLOOD_Leukemia

Explore this box plot interactively →