FDXR

Across TCGA patient cohorts, FDXR mutation is significantly associated with the RNA expression of many other genes, with 830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FDXR-associated genes across cancer lineages are NANOGNBP2, NICN2P, and CTLA4. Each is linked with FDXR in more than 2 cancer types. Because this analysis shows association rather than direction, both FDXR-to-partner and partner-to-FDXR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NANOGNBP2 grouped by FDXR-low versus FDXR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FDXR→partner) and Y-score (partner→FDXR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NANOGNBP2 →	+0.102	+1.687	.007	.009	3	3
COAD	NICN2P →	+0.109	+3.285	.003	.003	3	3
UCEC	CTLA4 →	+0.711	+2.545	.003	.001	3	2
UCEC	SFXN1 →	+0.390	+3.191	.009	.009	3	2
UCEC	KIR3DL1 →	+0.272	+3.449	<.001	<.001	3	2
SKCM	RNU7-19P →	+0.282	+3.776	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 830 associations by consensus.

NANOGNBP2 by FDXR expression — UCEC

Explore this box plot interactively →