FDXR

Across TCGA pan-cancer cohorts, FDXR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FDXR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FDXR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FDXR is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where FDXR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FDXR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.379	<.001	12	view →
KIRP	Female	II,III,IV	+2.191	<.001	11	view →
COAD	Female	All	+1.004	<.001	11	view →
LIHC	Female	All	+0.904	<.001	9	view →
BLCA	All	All	+1.036	<.001	8	view →
BRCA	All	III,IV	+0.995	<.001	6	view →
KICH	Female	II,III,IV	−1.121	<.001	5	view →
THCA	Female	All	+0.480	<.001	5	view →
LUSC	Male	All	+0.770	<.001	4	view →
CHOL	All	All	+0.902	<.001	3	view →
STAD	All	II,III,IV	+0.808	.003	3	view →
HNSC	Male	All	+0.480	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FDXR–KIRC

Open the KIRC breakdown →