FDXR

Across TCGA pan-cancer cohorts, FDXR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FDXR data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FDXR RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FDXR expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRP show a favorable association.

UCEC, KIRP, and MESO are the cancer types where FDXR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.691	0.599	.003	66	view →
KIRP	OS	Median	II,III,IV	0.981	0.719	<.001	55	view →
MESO	OS	Median	III,IV	0.427	0.686	<.001	42	view →
UCS	DFS	Tertile	IV	0.298	0.860	.024	30	view →
STAD	DFS	Median	III,IV	0.585	0.388	.006	29	view →
UVM	DFS	Quartile	III,IV	0.767	0.283	.009	27	view →
CHOL	OS	Median	II,III,IV	0.326	0.799	.010	24	view →
BRCA	OS	Tertile	III,IV	0.965	0.860	.002	21	view →
CESC	OS	Quartile	III,IV	0.827	0.410	.006	20	view →
THCA	DFS	Median	All	0.977	0.908	.003	19	view →
LGG	OS	Median	All	0.844	0.940	<.001	16	view →
LIHC	OS	Median	III,IV	0.506	0.198	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FDXR–UCEC (DFS)

Open the UCEC breakdown →