FDXR

Across TCGA cell cohorts, FDXR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,588 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FDXR-associated GO terms across cancer lineages are Regulation of pentose-phosphate shunt, Response to vitamin B1, and Cellular response to cell-matrix adhesion. Each is linked with FDXR in more than 11 cancer types. Because this analysis shows association rather than direction, both FDXR-to-partner and partner-to-FDXR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of pentose-phosphate shunt grouped by FDXR-low versus FDXR-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FDXR→partner) and Y-score (partner→FDXR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of pentose-phosphate shunt →	+0.172	+1.137	<.001	<.001	3	12
KIDNEY	Response to vitamin B1 →	+0.174	+1.818	<.001	<.001	3	12
KIDNEY	Cellular response to cell-matrix adhesion →	+0.282	+1.284	.001	.006	3	9
SKIN	Negative regulation of purine nucleotide metabolic process →	+0.109	+1.150	<.001	<.001	3	9
BLOOD_Lymphoma	Mitral valve formation →	+0.966	+1.173	<.001	<.001	3	9
SKIN	Negative regulation of nucleotide metabolic process →	+0.109	+1.150	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,588 associations by consensus.

Regulation of pentose-phosphate shunt by FDXR expression — SKIN

Explore this box plot interactively →