FDPS

Across TCGA patient cohorts, FDPS mutation is significantly associated with the RNA expression of many other genes, with 981 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FDPS-associated genes across cancer lineages are MIR4652, RNU6-662P, and RN7SL20P. Each is linked with FDPS in more than 2 cancer types. Because this analysis shows association rather than direction, both FDPS-to-partner and partner-to-FDPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4652 grouped by FDPS-low versus FDPS-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FDPS→partner) and Y-score (partner→FDPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4652 →	+0.559	+4.211	.006	.009	3	3
LUSC	RNU6-662P →	+0.315	+4.706	<.001	.007	3	2
BLCA	RN7SL20P →	+0.180	+4.208	.002	.009	3	2
COAD	RPL19P1 →	+0.423	+3.910	<.001	.006	3	2
COAD	NDUFS5P5 →	+0.452	+4.374	<.001	.002	3	2
COAD	RPS4XP15 →	+0.250	+4.289	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 981 associations by consensus.

MIR4652 by FDPS expression — LUSC

Explore this box plot interactively →