FDPS

Across TCGA pan-cancer cohorts, FDPS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FDPS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FDPS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FDPS is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

COAD, BLCA, and LIHC are the cancer types where FDPS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FDPS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.422	<.001	11	view →
BLCA	All	III,IV	+1.131	<.001	11	view →
LIHC	Male	All	+1.820	<.001	9	view →
KICH	Female	All	−1.639	<.001	8	view →
HNSC	Male	III,IV	+0.711	<.001	7	view →
BRCA	All	III,IV	+0.758	<.001	6	view →
KIRP	Male	All	−0.583	<.001	3	view →
STAD	All	All	+0.434	.004	3	view →
UCEC	All	All	+0.488	.020	2	view →
KIRC	Female	All	+0.323	.006	2	view →
LUSC	All	All	+0.250	.012	2	view →
ESCA	All	All	+0.878	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FDPS–COAD

Open the COAD breakdown →