FCMR

Across TCGA patient cohorts, FCMR mutation is significantly associated with the RNA expression of many other genes, with 2,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCMR-associated genes across cancer lineages are TMEM97P2, COX5A, and MRPS16. Each is linked with FCMR in more than 1 cancer types. Because this analysis shows association rather than direction, both FCMR-to-partner and partner-to-FCMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM97P2 grouped by FCMR-low versus FCMR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCMR→partner) and Y-score (partner→FCMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM97P2 →	+0.174	+4.516	<.001	.009	3	2
UCEC	COX5A →	+0.431	+3.740	.002	<.001	3	2
UCEC	MRPS16 →	+0.411	+4.119	.009	<.001	3	2
UCEC	C12orf60 →	+0.387	+3.492	<.001	.002	3	2
UCEC	KMT5A →	+0.561	+3.748	<.001	<.001	3	2
UCEC	VPS33B →	+0.366	+3.021	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,104 associations by consensus.

TMEM97P2 by FCMR expression — COAD

Explore this box plot interactively →