FCMR

Across TCGA pan-cancer cohorts, FCMR RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FCMR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FCMR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FCMR is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where FCMR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCMR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.620	<.001	11	view →
COAD	Female	II,III,IV	−1.324	<.001	9	view →
LUSC	All	II,III,IV	−1.149	<.001	7	view →
BRCA	All	III,IV	+1.115	<.001	6	view →
HNSC	Female	III,IV	+1.111	.003	6	view →
STAD	All	All	+1.325	.003	5	view →
BLCA	All	All	−1.112	.018	4	view →
KICH	Male	II,III,IV	−1.028	.043	2	view →
UCEC	All	All	−0.800	.001	2	view →
THCA	All	All	−0.635	.027	2	view →
ESCA	All	All	+1.184	.028	1	view →
THCA	Male	IV	+0.993	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

FCMR–KIRC

Open the KIRC breakdown →