FCGR3B

Across TCGA patient cohorts, FCGR3B mutation is significantly associated with the RNA expression of many other genes, with 329 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCGR3B-associated genes across cancer lineages are RNU6-376P, RNU5A-7P, and SNAPC2. Each is linked with FCGR3B in more than 2 cancer types. Because this analysis shows association rather than direction, both FCGR3B-to-partner and partner-to-FCGR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-376P grouped by FCGR3B-low versus FCGR3B-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGR3B→partner) and Y-score (partner→FCGR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-376P →	+0.377	+6.468	<.001	.001	3	3
LUAD	RNU5A-7P →	+0.307	+4.285	.007	.003	3	2
UCEC	SNAPC2 →	+0.520	+2.595	.004	.006	3	2
UCEC	DAPK3 →	+0.497	+3.330	.005	.005	3	2
UCEC	FGFR2 →	-1.245	-3.700	.002	.001	3	2
UCEC	CDC34 →	+0.546	+3.483	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 329 associations by consensus.

RNU6-376P by FCGR3B expression — HNSC

Explore this box plot interactively →