FCGR3B

Across TCGA pan-cancer cohorts, FCGR3B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FCGR3B data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher FCGR3B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FCGR3B expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UVM, UCEC, and KICH are the cancer types where FCGR3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.423	0.715	.001	53	view →
UCEC	DFS	Median	II,III,IV	0.723	0.268	.002	34	view →
KICH	OS	Tertile	II,III,IV	0.878	1.000	.012	20	view →
COAD	OS	Tertile	III,IV	0.947	0.681	.005	19	view →
LGG	OS	Median	All	0.390	0.515	<.001	18	view →
ESCA	OS	Median	All	0.647	1.000	.015	18	view →
ACC	OS	Quartile	II,III,IV	0.229	0.745	.003	17	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	17	view →
HNSC	DFS	Quartile	III,IV	0.673	0.496	.007	15	view →
BRCA	OS	Tertile	IV	0.434	0.876	.002	14	view →
LIHC	DFS	Quartile	III,IV	0.400	0.119	.012	11	view →
MESO	DFS	Quartile	IV	0.500	0.094	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FCGR3B–UVM (DFS)

Open the UVM breakdown →