FCGR2A

Across TCGA cell cohorts, FCGR2A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FCGR2A-associated genes across cancer lineages are OR5AU1, KRTAP2-1, and BPIFB6. Each is linked with FCGR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGR2A-to-partner and partner-to-FCGR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by FCGR2A-low versus FCGR2A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGR2A→partner) and Y-score (partner→FCGR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR5AU1 →	+0.030	+4.269	<.001	.005	3	1
LUNG_SCLC	KRTAP2-1 →	+0.133	+4.269	<.001	.005	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	RNASE8 →	+0.042	+3.345	<.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+3.766	.004	.004	3	1
LARGE_INTESTINE	CEACAM16 →	+0.070	+3.841	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR5AU1 by FCGR2A expression — LUNG_SCLC

Explore this box plot interactively →