FCGBP

Across TCGA patient cohorts, FCGBP mutation is significantly associated with the RNA expression of many other genes, with 9,585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCGBP-associated genes across cancer lineages are PCCB, SPAG5, and MCM6. Each is linked with FCGBP in more than 6 cancer types. Because this analysis shows association rather than direction, both FCGBP-to-partner and partner-to-FCGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCCB grouped by FCGBP-low versus FCGBP-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGBP→partner) and Y-score (partner→FCGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCCB →	+0.591	+2.346	<.001	.002	3	7
STAD	SPAG5 →	+0.702	+3.601	.001	.001	3	7
STAD	MCM6 →	+0.555	+3.584	.001	.002	3	6
LUSC	OTX1 →	+0.781	+2.819	<.001	<.001	3	6
STAD	KIF22 →	+0.588	+2.845	<.001	.001	3	6
HNSC	SLC25A33 →	+0.603	+3.339	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,585 associations by consensus.

PCCB by FCGBP expression — STAD

Explore this box plot interactively →