FCGBP

Across TCGA pan-cancer cohorts, FCGBP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FCGBP data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FCGBP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FCGBP expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, UVM, and OV are the cancer types where FCGBP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.678	0.525	<.001	144	view →
UVM	OS	Median	All	0.854	0.523	<.001	88	view →
OV	OS	Median	All	0.620	0.754	<.001	82	view →
KICH	OS	Median	II,III,IV	0.871	1.000	.002	80	view →
UCEC	DFS	Tertile	III,IV	0.858	0.682	.004	62	view →
LIHC	DFS	Quartile	All	0.388	0.591	<.001	53	view →
LGG	OS	Median	All	0.381	0.532	<.001	51	view →
COAD	DFS	Median	All	0.785	0.589	<.001	47	view →
ESCA	DFS	Median	II,III,IV	0.374	1.000	.006	23	view →
LUAD	OS	Quartile	All	0.864	0.748	.008	20	view →
BRCA	DFS	Tertile	All	0.649	0.466	.005	15	view →
READ	OS	Median	All	0.968	0.835	.027	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FCGBP–HNSC (DFS)

Open the HNSC breakdown →