FCGBP

Across TCGA pan-cancer cohorts, FCGBP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FCGBP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FCGBP RNA is repressed in tumor relative to normal tissue. In most cancer types FCGBP is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where FCGBP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCGBP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−3.564	<.001	11	view →
COAD	Female	All	−3.306	<.001	10	view →
KICH	Male	All	−2.988	<.001	9	view →
HNSC	Male	II,III,IV	−1.628	<.001	9	view →
BRCA	All	II,III,IV	−0.960	<.001	6	view →
LIHC	All	All	+0.693	<.001	6	view →
KIRC	All	All	−0.748	.003	5	view →
KIRP	All	IV	+3.017	.019	4	view →
LUAD	Female	All	+1.104	<.001	4	view →
PRAD	All	All	−0.971	.001	2	view →
READ	All	All	−3.484	.021	1	view →
CHOL	All	All	+2.247	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FCGBP–THCA

Open the THCA breakdown →