FCGBP

Across TCGA patient cohorts, FCGBP mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FCGBP-associated genes across cancer lineages are ASNS, Cyclin-B1, and PCNA. Each is linked with FCGBP in more than 4 cancer types. Because this analysis shows association rather than direction, both FCGBP-to-partner and partner-to-FCGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FCGBP-low versus FCGBP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGBP→partner) and Y-score (partner→FCGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.329	+1.064	.002	.039	3	5
STAD	Cyclin-B1 →	+0.421	+2.115	.020	.017	3	4
COAD	PCNA →	+0.204	+1.449	.008	.014	3	4
UCEC	ATM →	-0.516	-1.621	<.001	<.001	3	4
COAD	Paxillin →	-0.321	-1.807	.003	.022	3	3
LUAD	PRDX1 →	+0.303	+3.186	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

ASNS by FCGBP expression — SKCM

Explore this box plot interactively →