FCGBP

Across TCGA cell cohorts, FCGBP mutation is significantly associated with the RNA expression of many other genes, with 1,180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FCGBP-associated genes across cancer lineages are CCDC134, RBFA, and GSR. Each is linked with FCGBP in more than 3 cancer types. Because this analysis shows association rather than direction, both FCGBP-to-partner and partner-to-FCGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by FCGBP-low versus FCGBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGBP→partner) and Y-score (partner→FCGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC134 →	+0.681	+3.716	<.001	<.001	3	3
LARGE_INTESTINE	RBFA →	+0.729	+2.672	<.001	<.001	3	3
LARGE_INTESTINE	GSR →	+0.706	+2.043	.002	.001	3	3
LARGE_INTESTINE	MRPL37 →	+0.455	+2.129	<.001	.001	3	3
LARGE_INTESTINE	BCAS2 →	+0.523	+2.649	<.001	.001	3	3
LARGE_INTESTINE	RPA2 →	+0.427	+2.584	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,180 associations by consensus.

CCDC134 by FCGBP expression — LARGE_INTESTINE

Explore this box plot interactively →