FBXW8

Across TCGA cell cohorts, FBXW8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXW8-associated genes across cancer lineages are REG1B, OR1A1, and OR5B21. Each is linked with FBXW8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW8-to-partner and partner-to-FBXW8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by FBXW8-low versus FBXW8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW8→partner) and Y-score (partner→FBXW8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+3.008	+3.196	<.001	.007	3	2
URINARY_TRACT	OR1A1 →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	OR5B21 →	+0.026	+5.087	<.001	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	PPP1R42 →	+0.098	+3.781	.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.279	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

REG1B by FBXW8 expression — LARGE_INTESTINE

Explore this box plot interactively →