FBXW8

Across TCGA pan-cancer cohorts, FBXW8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FBXW8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FBXW8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXW8 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

KIRP, THCA, and COAD are the cancer types where FBXW8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.108	<.001	11	view →
THCA	All	II,III,IV	−0.848	<.001	10	view →
COAD	Female	All	+0.689	<.001	10	view →
LIHC	All	II,III,IV	+0.786	<.001	8	view →
HNSC	All	All	+0.514	<.001	7	view →
BRCA	All	II,III,IV	+0.300	<.001	6	view →
CHOL	Male	All	+1.885	<.001	5	view →
BLCA	Female	III,IV	+0.741	.002	5	view →
LUSC	All	All	+0.279	.005	3	view →
STAD	Male	II,III,IV	+0.606	.018	2	view →
UCEC	All	All	−0.484	.006	2	view →
PRAD	All	All	+0.301	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FBXW8–KIRP

Open the KIRP breakdown →