FBXW4

Across TCGA patient cohorts, FBXW4 mutation is significantly associated with the RNA expression of many other genes, with 335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW4-associated genes across cancer lineages are SIGLEC27P, ATG16L1, and ENSAP3. Each is linked with FBXW4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW4-to-partner and partner-to-FBXW4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC27P grouped by FBXW4-low versus FBXW4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW4→partner) and Y-score (partner→FBXW4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SIGLEC27P →	+0.110	+5.392	<.001	.002	3	2
UCEC	ATG16L1 →	+0.558	+3.459	<.001	.005	3	2
COAD	ENSAP3 →	+0.165	+4.693	.006	.007	3	2
BRCA	P3R3URF-PIK3R3 →	+0.034	+5.575	<.001	.004	3	1
SKCM	KRT18P51 →	+0.153	+3.747	<.001	<.001	3	1
SKCM	OPCML-IT2 →	+0.050	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

SIGLEC27P by FBXW4 expression — COAD

Explore this box plot interactively →