FBXW4

Across TCGA pan-cancer cohorts, FBXW4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FBXW4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where FBXW4 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXW4 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LIHC, and LUAD are the cancer types where FBXW4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.054	.001	8	view →
LIHC	Female	II,III,IV	+1.028	<.001	8	view →
LUAD	Male	All	−0.746	<.001	8	view →
BRCA	All	II,III,IV	−0.325	<.001	6	view →
READ	All	II,III,IV	−0.557	.021	5	view →
LUSC	Male	All	−0.531	<.001	4	view →
THCA	All	All	−0.142	.013	4	view →
CHOL	Female	All	+1.933	<.001	3	view →
KIRP	All	IV	+0.639	.007	2	view →
STAD	Female	All	−0.565	.005	2	view →
KIRC	Female	All	+0.291	.022	2	view →
KICH	Male	All	−0.479	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FBXW4–BLCA

Open the BLCA breakdown →