FBXW4

Across TCGA cell cohorts, FBXW4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXW4-associated genes across cancer lineages are MAS1, KLRD1, and SLC22A7. Each is linked with FBXW4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW4-to-partner and partner-to-FBXW4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAS1 grouped by FBXW4-low versus FBXW4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW4→partner) and Y-score (partner→FBXW4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAS1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	KLRD1 →	+0.047	+3.707	.004	.009	3	1
LARGE_INTESTINE	SLC22A7 →	+0.065	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SLC25A31 →	+0.052	+3.793	.002	.007	3	1
LARGE_INTESTINE	NLRP13 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	OR5P3 →	+0.172	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MAS1 by FBXW4 expression — LARGE_INTESTINE

Explore this box plot interactively →