FBXW2

Across TCGA patient cohorts, FBXW2 mutation is significantly associated with the RNA expression of many other genes, with 289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW2-associated genes across cancer lineages are TRIM64EP, VTRNA2-2P, and PRAMEF28P. Each is linked with FBXW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW2-to-partner and partner-to-FBXW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64EP grouped by FBXW2-low versus FBXW2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW2→partner) and Y-score (partner→FBXW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRIM64EP →	+0.033	+4.969	<.001	.004	3	2
CESC	VTRNA2-2P →	+0.526	+4.601	<.001	.004	3	2
CESC	PRAMEF28P →	+0.046	+4.969	.004	.004	3	2
SKCM	LINC00400 →	+0.111	+4.495	<.001	.007	3	2
BLCA	NDUFA5P3 →	+0.172	+2.570	.009	.009	3	2
BLCA	RPS27P27 →	+0.127	+3.200	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 289 associations by consensus.

TRIM64EP by FBXW2 expression — CESC

Explore this box plot interactively →