FBXW12

Across TCGA patient cohorts, FBXW12 mutation is significantly associated with the RNA expression of many other genes, with 697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW12-associated genes across cancer lineages are RN7SL93P, ZNF70P1, and RN7SKP52. Each is linked with FBXW12 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW12-to-partner and partner-to-FBXW12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL93P grouped by FBXW12-low versus FBXW12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW12→partner) and Y-score (partner→FBXW12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL93P →	+0.031	+4.025	<.001	.007	3	2
BRCA	ZNF70P1 →	+0.095	+5.926	<.001	.002	3	2
BRCA	RN7SKP52 →	+1.002	+5.288	<.001	.006	3	2
UCEC	H3C11 →	+0.512	+2.828	.006	.001	3	2
COAD	RNA5SP286 →	+0.452	+4.308	.004	.009	3	2
BRCA	LINC02400 →	+0.678	+5.148	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 697 associations by consensus.

RN7SL93P by FBXW12 expression — SKCM

Explore this box plot interactively →