FBXW12

Across TCGA patient cohorts, FBXW12 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW12-associated genes across cancer lineages are FoxM1, INPP4B, and JNK2. Each is linked with FBXW12 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW12-to-partner and partner-to-FBXW12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FBXW12-low versus FBXW12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW12→partner) and Y-score (partner→FBXW12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.427	+3.700	<.001	.001	3	1
UCEC	INPP4B →	-0.379	-2.321	.011	.033	3	1
UCEC	JNK2 →	+0.220	+2.834	.017	.034	3	1
UCEC	MEK1 →	+0.387	+3.459	.023	.005	3	1
UCEC	p27_pT198 →	+0.126	+3.169	.011	.019	3	1
UCEC	p38-MAPK →	-0.183	-2.584	.016	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FoxM1 by FBXW12 expression — UCEC

Explore this box plot interactively →