FBXW12

Across TCGA cell cohorts, FBXW12 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,524 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FBXW12-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of DNA-templated transcription elongation, and Positive regulation of DNA repair. Each is linked with FBXW12 in more than 9 cancer types. Because this analysis shows association rather than direction, both FBXW12-to-partner and partner-to-FBXW12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by FBXW12-low versus FBXW12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW12→partner) and Y-score (partner→FBXW12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.097	+0.150	<.001	<.001	3	10
BONE	Regulation of DNA-templated transcription elongation →	+0.070	+0.130	.002	.002	3	10
BONE	Positive regulation of DNA repair →	+0.104	+0.183	<.001	<.001	3	10
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.093	+0.246	<.001	<.001	3	10
BONE	Protein localization to cytoplasmic stress granule →	+0.158	+0.151	<.001	.002	3	10
BONE	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.186	+0.222	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,524 associations by consensus.

Positive regulation of double-strand break repair by FBXW12 expression — BONE

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