FBXW12

Across TCGA cell cohorts, FBXW12 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FBXW12-associated genes across cancer lineages are OR2M5, OR7D4, and LCE1C. Each is linked with FBXW12 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW12-to-partner and partner-to-FBXW12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by FBXW12-low versus FBXW12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW12→partner) and Y-score (partner→FBXW12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR7D4 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	LCE1C →	+0.065	+4.684	.007	.002	3	1
SKIN	ZIM3 →	+0.005	+3.700	<.001	.009	3	1
SKIN	CATSPERD →	+0.058	+3.263	.004	.006	3	1
SKIN	TPPP2 →	+0.048	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2M5 by FBXW12 expression — LARGE_INTESTINE

Explore this box plot interactively →