FBXO8

Across TCGA patient cohorts, FBXO8 mutation is significantly associated with the RNA expression of many other genes, with 1,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO8-associated genes across cancer lineages are TDGF1P4, RN7SL413P, and IMMP1LP2. Each is linked with FBXO8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO8-to-partner and partner-to-FBXO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TDGF1P4 grouped by FBXO8-low versus FBXO8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO8→partner) and Y-score (partner→FBXO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TDGF1P4 →	+0.112	+4.693	<.001	.007	3	2
COAD	RN7SL413P →	+0.504	+5.374	<.001	.001	3	2
READ	IMMP1LP2 →	+0.172	+5.421	<.001	.005	3	2
HNSC	EIF3JP1 →	+0.124	+3.654	.009	.009	3	2
HNSC	RNU6-335P →	+0.421	+4.141	<.001	.003	3	1
UCEC	ARF4P1 →	+0.382	+1.925	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,111 associations by consensus.

TDGF1P4 by FBXO8 expression — COAD

Explore this box plot interactively →