FBXO8

Across TCGA pan-cancer cohorts, FBXO8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FBXO8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FBXO8 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXO8 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KIRP are the cancer types where FBXO8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.259	<.001	11	view →
COAD	Female	All	−0.617	<.001	7	view →
KIRP	Male	All	−0.586	<.001	7	view →
LUSC	All	All	−0.435	<.001	7	view →
UCEC	All	All	−1.190	<.001	6	view →
LUAD	Female	III,IV	−0.771	<.001	6	view →
BLCA	All	All	−0.542	.006	6	view →
KIRC	Male	II,III,IV	−0.366	<.001	6	view →
BRCA	Female	All	−0.282	<.001	4	view →
KICH	All	All	−0.450	.003	3	view →
READ	All	All	−0.761	.002	2	view →
STAD	All	All	−0.302	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FBXO8–THCA

Open the THCA breakdown →